However, large-scale research studies are necessary to determine whether all these natural supplements and medicines are safe and effective.įor example, researchers also still need to know how much a person should take and whether the substances will interact with other medications. Studies have suggested it might reduce restlessness and improve self-control. Bacopa: This traditional Indian or Ayurvedic treatment derives from a plant also known as Brahmi or water hyssop.Ningdong: Another Chinese remedy that may help reduce some ADHD symptoms.Ginseng: This Chinese herb may alleviate hyperactivity and inattentiveness. French maritime pine bark extract: This plant-based material may increase visual-motor coordination and reduce hyperactivity and inattentiveness.Therefore, people must always check with a doctor whether it is safe to use a supplement or other remedy and what dosage they should take.Ĭlinical trials have found that several herbal treatments may show promise for treating ADHD. As a result, there is no regulation or recommended dosages regarding their contents. In particular, children should not take any supplementary or complementary medications without their doctor’s approval.Īdditionally, most supplements do not have approval from the Food and Drug Administration (FDA). The use of any medication, including supplements, carries some risk. Omega-3: Fish oils, for example, may help treat symptoms of ADHD, though the effect appears to be small.Iron, zinc, and magnesium: These may help if a person has a deficiency in any of these, but more research is necessary to confirm the effectiveness of taking supplements.Melatonin: This may help reduce insomnia, but there is no evidence that it reduces ADHD symptoms.Only Takeda Pharmaceutical's ( TAK) Mydayis ER (mixed amphetamine salts), currently lasts as long.According to a 2014 review, some evidence supports the use of the following supplements for treating ADHD symptoms: The one stimulant medication in phase 3 development mentioned in the GlobalData report, CTx-1301 from Cingulate ( NASDAQ: CING), could become a first-line treatment that rivals currently available therapies if it can provide 16 hours of treatment coverage for each dose. If this could be addressed, new non-stimulant medications could provide a competitive edge over currently marketed versions. KOLs also identified the lack of dosing flexibility associated with non-stimulants as an issue. The consulting and analytical firm, however, noted that based on feedback from key opinion leaders, non-stimulants are unlikely to topple stimulants from their perch as the first-line ADHD treatment without the efficacy match. They are: solriamfetol from Axsome Therapeutics ( NASDAQ: AXSM), centanafadine from Otsuka ( OTCPK:OTSKF)( OTCPK:OTSKY), and l-threonate magnesium salt from privately held Neurocentria. The good news is three out of the four ADHD drugs in late-stage development are non-stimulants. "A further competitive edge for pipeline non-stimulants would be to address the symptoms of co-morbidities common with ADHD, such as autism spectrum disorder and emotional instability," noted GlobalData Pharma analyst Lorraine Palmer. Though there are non-stimulant drugs on the market for ADHD, they are usually relegated to second-line treatments as their efficacy is not as robust as stimulant meds.Ī non-stimulant drug that can at least match the efficacy of a stimulant drug for ADHD could present a significant opportunity for drugmakers, according to a new report from GlobalData. They are considered Schedule II controlled substances, and have a risk for dependency and abuse. While effective, the stimulant drugs have drawbacks. Pharmaceutical companies would be wise to pay attention to developing new treatments for ADHD as there is a demand for improved drugs in the space.Ĭurrently, the medications of choice for the condition are stimulant drugs, such as Takeda's ( NYSE: TAK ) Vyvanse (lisdexamfetamine), and Johnson & Johnson ( JNJ ) unit Janssen's Concerta (methylphenidate).
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